Human Prion Protein V129 Prevents Expression of Variant CJD Phenotype
نویسندگان
چکیده
Materials and Methods Transgenic mice. Transgenic mice homozygous for a human PrP 129V transgene array and murine PrP null alleles (Prnp) designated Tg(HuPrP129V Prnp)-152 mice (129VV Tg152 mice) and transgenic mice homozygous for a human PrP 129M transgene array and murine PrP null alleles (Prnp) designated Tg(HuPrP129M Prnp)-35 mice (129MM Tg35 mice) have been described previously (S1-S4). Inbred FVB/NHsd mice were supplied by Harlan UK, Ltd.
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